I currently use a G3258 (no O/C) in my cab with a Radeon 6800 HD.
Off the top of my head, I run MAME, Sammy, Daphne, TTX, PSX, PS2, PSP, GC, Wii, N64, NES, SNES, DC, MD, MS and some fully cab-controlled PC stuff (like Injustice, MK Komplete, Ultra SF IV plus some sh'mups such as Crimson Clover etc) on the cab.
Model 2, Model 3 and Naomi have not been tested yet but will eventually.
The only exception to the cab-controlled PC stuff is the PopCap pack for the wife (uses the mouse)!
Never had an issue with any of them and everything is ran at its native resolution of the emulated hardware.
MAME uses HLSL filters and RetroArch uses filters for scanlines and curveture etc.
I know it chokes on SF V though... but no biggie with that one.